|
|
|
|
Streptokinase(alone or with aspirin)was associated with an excess of 10- day case fatality(odds ratio 2.7;95%confidence interval 1.7-4.3;2p<0. 00001).Of the four groups randomised,only patients allocated to streptokinase plus aspirin had a significantly higher risk of early death than those given neither streptokinase nor aspirin(odds ratio 3.5;95%CI 1. 9-6.5;2p<0.00001).Streptokinase(alone or with aspirin)and aspirin(alone or with streptokinase)reduced,albeit not significantly,the incidence of combined six-month case fatality and severe disability;odds ratio for streptokinase 0.9(95%CI 0.7-1.3)and odds ration for aspirin 0.9(95%CI 0.6- 1.3).The risk of early death with thrombolytic treatments should be weighed against the potential benefit of a marginal reduction of severe disability after the first six months. |
|